The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery by

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The Pancreas

by Hans G. Beger, Andrew L. Warshaw, Ralph H. Hruban, Markus W. Buchler, John P. Neoptolemos, Tooru Shimosegawa, David C. Whitcomb, Julia Mayerle, Yupei Zhao

The PANCREASThe newest edition of the essential guide to pancreatic medicine The fourth edition of The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery integrates the cutting-edge research of recent years to update its presentation of this fast-growing subject. It details every known disorder of the pancreas, grounding them in a thorough understanding of pancreatic function, enhanced with high quality illustration and graphs. It also includes step-by-step guidance for relevant endoscopic techniques and surgical procedures. The Pancreas readers will also find:

  • New comprehensive insights into three pancreatic diseases: autoimmune pancreatitis, cystic neoplasms, and neuroendocrine tumors
  • An editorial team with decades of clinical and research experience in the US, Europe, and Asia
  • Over 500 downloadable illustrations for use in scientific presentations
The Pancreas is a foundational reference for clinicians and researchers in gastroenterology and gastrointestinal surgery.

FORMAT Hardcover CONDITION Brand New

Author Biography

Hans G. Beger, MD, FACS (Hon.), JSS (Hon.), CSS (Hon.), Professor Emeritus of Surgery, University of Ulm, Ulm, Germany. Markus W. Büchler, MD, FACS (Hon.), FRCS (Hon.), FASA (Hon.) Professor of Surgery, University of Heidelberg, Heidelberg, Germany. Ralph H. Hruban, MD, Baxley Professor and Director, Department of Pathology and Director of the Sol Goldman Pancreatic Research Center, Johns Hopkins University School of Medicine, Baltimore, USA. Julia Mayerle, MD, Professor of Internal Medicine, Gastroenterology and Hepatology, Chair Department of Medicine II, LMU Klinikum, Ludwig-Maximilians-University, Munich, Germany. John P. Neoptolemos, MA, MB, BCHIR, MD FRCS, FMEDSCI, MAE Professor of Surgery, Department of Surgery, University of Heidelberg, Heidelberg, Germany. Tooru Shimosegawa, MD, PhD, Professor Emeritus Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Andrew L. Warshaw, MD, FACS, FRCSEd (Hon.), W. Gerald Austen Distinguished Professor of Surgery, Harvard Medical School, and Surgeon-in-Chief Emeritus, Massachusetts General Hospital, Boston, USA. David C. Whitcomb, MD, PhD, Professor of Medicine, Cell Biology & Physiology, and Human Genetics, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh and UPMC, Pennsylvania, USA. Yupei Zhao, MD, FICS (Hon.), FACS (Hon.), FRCS (Engl) (Hon.), FCSHK (Hon.), Professor of Surgery, Department of General Surgery, Peking Union Medical College Hospital, Beijing, P.R. China.

Table of Contents

About the Companion Website xvii Section 1 Anatomy of the Pancreas 1 1 Development of the Pancreas and Related Structures 3
Brian Lewis and Junhao Mao 2 Anatomy, Histology, and Fine Structure of the Pancreas 9
Daniel S. Longnecker and Elizabeth D. Thompson 3 Congenital and Inherited Anomalies of the Pancreas 23
Heiko Witt and Martin Zenker Section 2 Physiology and Pathophysiology of Pancreatic Functions 33 4 Physiology of Acinar Cell Secretion 35
Ole H. Petersen 5 Physiology of Duct Cell Secretion 48
Wei- Yin Lin, Paramita Sarkar, and Shmuel Muallem 6 Physiology and Pathophysiology of Function of Sphincter of Oddi 56
Savio George Barreto and James Toouli 7 Neurohormonal and Hormonal Control of Pancreatic Secretion 65
Chung Owyang and Matthew J. DiMagno 8 Regulation of Pancreatic Protein Synthesis and Growth 75
Maria Dolors Sans and John A. Williams 9 Fibrogenesis in the Pancreas: The Role of Pancreatic Stellate Cells 86
Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson 10 Pancreatic Endocrine–Exocrine Relationship 98
Kenichiro Furuyama and Yoshiya Kawaguchi Section 3 Acute Pancreatitis 105 11 Epidemiology and Etiology of Alcohol- Induced Pancreatitis 107
Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte 12 Epidemiology and Etiology of Biliary Acute Pancreatitis 119
Ippei Ikoma, Ko Tomishima, and Hiroyuki Isayama 13 Genetic Factors in Acute Pancreatitis 128
Mitchell L. Ramsey and Georgios I. Papachristou 14 The Role of the Intestine and Mesenteric Lymph in the Development of Organ Dysfunction in Severe Acute Pancreatitis 138
Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor 15 The Role of Neurogenic Inflammation in Pancreatitis 146
Metrah Mohammad Nader and Jami L. Saloman 16 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis 155
Ujjwal M. Mahajan, F. Ulrich Weiss, Markus M. Lerch, and Julia Mayerle 17 Histopathology of Acute Pancreatitis 164
Günter Klöppel 18 Severity Classification of Acute Pancreatitis 170
John A. Windsor 19 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 176
Bettina M. Rau and Claus Schäfer 20 Acute Pancreatitis Associated with Congenital Anomalies 185
Charlotte S. Austin, Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit 21 Acute Pancreatitis in Children 191
Mark E. Lowe and Véronique D. Morinville 22 Acute Pancreatitis Associated with Metabolic, Infections and Drug- Related Diseases 199
Ali A. Aghdassi, Mats L. Wiese, Quang Trung Tran, and Markus M. Lerch 23 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 208
Yoshihisa Tsuji 24 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 222
Steven M. Hadley, Jr. and Timothy B. Gardner 25 ICU Treatment of Severe Acute Pancreatitis 230
Scott R. Gunn and David C. Whitcomb 26 Clinical Course and Medical Treatment of Acute Pancreatitis— Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 238
Rainer Isenmann and Mathias Wittau 27 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 244
Lily V. Saadat and Thomas E. Clancy 28 Management of Infected Necrosis: Step- Up Approach 254
Hester C. Timmerhuis, Marc G. Besselink, and Hjalmar C. van Santvoort 29 Management of Infected Pancreatic Necroses: An Endoscopic Approach 260
Todd H. Baron 30 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 266
Kulbir Mann and Michael G.T. Raraty 31 Open Surgical Debridement of Necrotizing Pancreatitis: Late Postoperative Morbidity and Outcome 271
Dongya Huang, Zipeng Lu, and Yi Miao 32 Endoscopic Treatment of Acute Biliary Pancreatitis 278
Ichiro Yasuda, Tsuyoshi Mukai, and Toru Ito 33 Strategies for the Treatment of Pancreatic Pseudocysts and Walled- Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches 284
Georg Beyer and Julia Mayerle 34 Pseudocysts and Walled- Off Necrosis After Acute Pancreatitis: Surgical Approach 288
Naohiro Sata, Masaru Koizumi, and Alan Kawarai Lefor 35 Management of Fluid Collection in Acute Pancreatitis 294
Georg Beyer, Simon Sirtl, Christoph Ammer- Herrmenau, and Albrecht Neesse 36 Management of Pancreatic Fistula in Acute Pancreatitis 300
Marta Sandini, Thilo Hackert, and Markus W. Büchler 37 Long- Term Outcome After Acute Pancreatitis 306
Christin Tjaden and Thilo Hackert Section 4 Chronic Pancreatitis 315 38 Definition and Classification of Chronic Pancreatitis 317
David C. Whitcomb 39 Molecular Understanding of Chronic Pancreatitis 326
Bomi Lee, Monique T. Barakat, and Sohail Z. Husain 40 Natural History of Recurrent Acute and Chronic Pancreatitis 334
Rohit Das, Jorge D. Machicado, and Dhiraj Yadav 41 Pediatric Recurrent Acute and Chronic Pancreatitis: Role of Pancreas Divisum 344
Jiri Snajdauf, Michal Rygl, Barbora Kucerova, and Natalia Newland 42 Clinical and Laboratory Diagnosis of Chronic Pancreatitis 349
Georg Beyer, Markus M. Lerch, and Julia Mayerle 43 Abdominal Imaging for the Diagnosis of Chronic Pancreatitis 357
Atsushi Irisawa and Akira Yamamiya 44 Endoscopic Ultrasound for Diagnosis of Chronic Pancreatitis Versus Pancreatic Cancer 366
J. Enrique Domínguez- Muñoz, Julio Iglesias- García, José Lariño- Noia, and Daniel de la Iglesia- García 45 Hereditary Pancreatitis and Complex Genetic Causes 375
Celeste Shelton Ohlsen and David C. Whitcomb 46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis 383
Shailesh V. Shrikhande and Savio G. Barreto 47 CFTR- Associated Pancreatic Disease 390
Chee Y. Ooi and Aliye Uc 48 Alcohol and Smoking in Chronic Pancreatitis 396
Atsushi Masamune, Kazuhiro Kikuta, and Kiyoshi Kume 49 Idiopathic and Rare Causes of Chronic Pancreatitis 404
Morihisa Hirota and Tooru Shimosegawa 50 Early Chronic Pancreatitis 412
Kazuhiro Kikuta and Atsushi Masamune 51 Chronic Pancreatitis with Inflammatory Mass in the Pancreatic Head 418
Ulrich F. Wellner, Kim C. Honselmann, and Tobias Keck 52 Structural Complications: Strictures, Stones, Pseudocysts, and Vascular Complications 424
Xiaodong Tian, Xiaochao Guo, and Yinmo Yang 53 Nutritional Evaluation and Support: An Overview 430
Sinead N. Duggan and Stephen J. O'Keefe 54 Exocrine Pancreatic Insufficiency 436
Chris E. Forsmark 55 Bone Disease in Chronic Pancreatitis 442
Sinead N. Duggan 56 Diabetes from Exocrine Pancreatic Disease 445
Nao Fujimori, Tetsuhide Ito, and Yoshihiro Ogawa 57 Oxidative Stress and Antioxidants in Chronic Pancreatitis 451
Soumya Jagannath Mahapatra and Pramod Kumar Garg 58 Pain Mechanisms in Chronic Pancreatitis 460
Pierluigi Di Sebastiano, Fabio Francesco di Mola, Tommaso Grottola, and Rossana Percario 59 Pain Management in Chronic Pancreatitis 467
Louise Kuhlmann, Søren S. Olesen, and Asbjørn M. Drewes 60 Adjunctive Therapy in Chronic Pancreatitis 474
Anna Evans Phillips 61 Pancreatic Cancer Risks in Chronic Pancreatitis 480
Patrick Maisonneuve and Albert B. Lowenfels 62 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts 486
Jörg Schirra, Simon Sirtl MD, Markus M. Lerch, and Julia Mayerle 63 Major Pancreatic Resection for Chronic Pancreatitis: Indication, Goals, and Limitations 496
Faik G. Uzunoglu and Jakob R. Izbicki 64 Pancreatic Drainage Procedures: Techniques and Results 501
Ulrich F. Wellner, Dirk Bausch, and Tobias Keck 65 Duodenum- Preserving Pancreatic Head Resections for Chronic Pancreatitis: Techniques and Results 506
Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar Uhl 66 Total Pancreatectomy with Islet Autotransplant 515
Greg Beilman, Zachary Bergman, and Melena Bellin 67 Minimally Invasive Surgical Management of Chronic Pancreatitis 523
Gilbert Z. Murimwa, Herbert J. Zeh III, and Matthew R. Porembka Section 5 Autoimmune Pancreatitis 533 68 Epidemiology of Autoimmune Pancreatitis 535
Terumi Kamisawa 69 Molecular Immunology and Pathogenesis of Autoimmune Pancreatitis 540
Yoh Zen 70 Clinical Manifestation of Type 1 Autoimmune Pancreatitis 546
Tooru Shimosegawa 71 Clinical Manifestation of Type 2 Autoimmune Pancreatitis 554
Nicolò de Pretis and Luca Frulloni 72 Clinical Diagnostic Criteria for Autoimmune Pancreatitis 561
Tooru Shimosegawa 73 Laboratory Diagnosis of Autoimmune Pancreatitis 568
J- Matthias Löhr and Miroslav Vujasinovic 74 What is the Evidence Measuring Immune Markers 573
Shigeyuki Kawa, Takayuki Watanabe, and Norihiro Ashihara 75 Autoimmune Pancreatitis and IgG4- Related Disease 579
Kazuichi Okazaki, Tsukasa Ikeura, and Kazushige Uchida 76 Imaging Diagnosis of Autoimmune Pancreatitis 595
Kazuichi Okazaki, Makoto Takaoka, Tsukasa Ikeura, and Kazushige Uchida 77 Medical Management of Autoimmune Pancreatitis 600
Shounak Majumder and Suresh T. Chari 78 Management of Intractable Autoimmune Pancreatitis 605
Shounak Majumder and Suresh T. Chari 79 Long- Term Outcome After Treatment of Autoimmune Pancreatitis 609
Luca Frulloni and Nicolò de Pretis Section 6 Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas 615 80 Epidemiology of Cystic Neoplasms of the Pancreas 617
Shounak Majumder and Suresh T. Chari 81 Histologic Classification and Staging of Cystic Neoplasms 623
Noriyoshi Fukushima and Giuseppe Zamboni 82 Molecular Mechanisms of Cystic Neoplasia- 630
Nickolas Papadopoulos and Ralph H. Hruban 83 Clinical Presentation of Pancreatic Cystic Neoplasms 638
Masao Tanaka 84 Evaluation of Cystic Lesions Using EUS, MRI, and CT 642
Anne Marie Lennon and Atif Zaheer 85 Cytologic Evaluation of Cystic Neoplasms: The Role of Liquid Biopsy 652
Abdulwahab Ewaz and Michelle D. Reid 86 Natural History of Cystic Neoplasms: IPMN, MCN, SCN, and SPN 666
Rosa Klotz, Thilo Hackert, and Markus W. Büchler 87 Surveillance or Surgical Treatment in Asymptomatic Cystic Neoplasm 674
Klaus Sahora and Carlos Fernández- del Castillo 88 Artificial Intelligence in the Detection and Surveillance of Cystic Neoplasms 680
Linda C. Chu and Elliot K. Fishman 89 Oncologic Resection of IPMN and MCN: Open ApproachResults 688
Marco Del Chiaro, Michael J. Kirsch, and Richard D. Schulick 90 Surgical Treatment of Cystic Neoplasms: Laparoscopic and Robotic Approach—Results 693
Benedict Kinny- Köster, Christopher L. Wolfgang, Markus W. Büchler, and Thilo Hackert 91 Robotic- assisted Resection of Cystic Neoplasms 700
Kimberly Kopecky and Jin He 92 Duodenum- preserving Pancreatic Head Resection for Cystic Neoplasms of the Pancreatic Head: Indications and Limitations 709
Hans G. Beger and Bertram Poch 93 Pancreatic Middle Segment Resection of Cystic Neoplasms: Indications and Limitations 715
Calogero Iacono and Mario De Bellis 0005474686.indd 11 05-25-2023 11:30:31 94 Tumor Enucleation for Cystic Neoplasms of the Pancreas: Indications and Limitations 723
Rachel C. Kim, C. Max Schmidt, and Henry A. Pitt 95 Duodenum- preserving Pancreatic Head Resection and Local Extirpation of SPTP in Children and Adolescents: Indications and long- term results 732
Jiri Snajdauf, Michal Rygl, Barbora Kucerova, and Natalia Newland 96 Management of Recurrence of Cystic Neoplasms 737
Anna Nießen, Christopher L. Wolfgang, Thilo Hackert, and Markus W. Büchler 97 Long- term Outcome after Observation and Surgical Treatment of Cystic Neoplasms: What is the Evidence? 744
Roberto Salvia, Giovanni Marchegiani, Giampaolo Perri, and Claudio Bassi Section 7 Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas 751 98 Epidemiology and Classification of Neuroendocrine Tumors of the Pancreas 753
J.J. Mukherjee, K.O. Lee, and Gregory Kaltsas 99 Pathology of Neuroendocrine Neoplasms 763
Atsuko Kasajima and Hironobu Sasano 100 Molecular Genetics of Neuroendocrine Tumors 771
Nickolas Papadopoulos and Ralph H. Hruban 101 What is the Origin of Pancreatic Endocrine Tumors? 781
Aurel Perren, Iacovos P. Michael, and Ilaria Marinoni 102 Clinical Manifestation of Endocrine Tumors of the Pancreas 791
Tetsuhide Ito, Keijiro Ueda, Nao Fujimori, and Robert T. Jensen 103 Evidence of Hormonal, Laboratory, Biochemical, and Instrumental Diagnostics of Neuroendocrine Tumors of the Pancreas 799
K.O. Lee, Gregory Kaltsas, and J.J. Mukherjee 104 Pancreatic Neuroendocrine Tumors in Multiple Neoplasia Syndromes 808
Anja Rinke and Thomas Matthias Gress 105 Nonfunctioning Pancreatic Neuroendocrine Neoplasms: Diagnosis and Management Principles 815
Takao Ohtsuka, Yuto Hozaka, and Hiroshi Kurahara 106 Medical and Nucleotide Treatment of Neuroendocrine Tumors of the Pancreas 820
Marina Tsoli and Gregory Kaltsas 107 Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors 829
Tetsuya Idichi, Hiroshi Kurahara, and Takao Ohtsuka 108 Enucleation of Benign, Neuroendocrine Tumors of the Pancreas 833
Frank Weber, Andreas Machens, and Henning Dralle 109 Duodenum- Preserving Pancreatic Head Resection or Local Extirpation of Neuroendocrine Tumors of the Pancreas Larger than 2 cm 841
Takashi Hatori 110 Individualized Surgery for Nonfunctional Pancreatic Neuroendocrine Tumors (NF- pNET)

Details ISBN1119875978 Year 2023 ISBN-10 1119875978 ISBN-13 9781119875970 Format Hardcover Country of Publication United States Pages 1360 NZ Release Date 2023-06-26 Edition 4th Subtitle An Integrated Textbook of Basic Science, Medicine, and Surgery Edited by Hans G. Beger UK Release Date 2023-08-24 Author Yupei Zhao Edition Description 4th edition DEWEY 616.37 Audience Professional & Vocational Publisher John Wiley and Sons Ltd Imprint Wiley-Blackwell Place of Publication Hoboken Publication Date 2023-08-21 US Release Date 2023-08-21 AU Release Date 2023-12-07

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  • Condition: Brand New
  • Format: Hardcover
  • ISBN-13: 9781119875970
  • Author: Hans G. Beger, Andrew L. Warshaw, Ralph H. Hruban
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  • Book Title: The Pancreas
  • Publication Name: NA
  • ISBN: 9781119875970

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